In 2000, Eidinger founded Mintwood Media Collective, which managed publicity for Dr. Bronner's Soap, a soap company who's owner and namesake was also Jewish. The company advocates for a number of social causes, one of which is the de-regulation of cannabis.

Bronner promoted the decriminalization or cannabis, and donated large sums of money to causes he thought to be righteous. His soap brand continues to support and advocate for these causes today.

Nadelmann has been described by Rolling Stone as "The driving force for the legalization of marijuana in America". He is known as a high-profile, divisive critic and commentator on domestic and foreign drug control policies.

Mechoulam first studied chemical engineering in Bulgaria in 1944, but claims to have disliked it. Later, upon immigrating to Israel in 1949, he studied chemistry. His first research experience was in the Israeli Army, working on insecticides.

Grinspoon also played a significant part in aiding the work of NORML (National Organization for the Reform of Marijuana Laws), a prominent DC nonprofit that advocates for cannabis law reform.